{"id":1954,"date":"2025-01-24T11:40:49","date_gmt":"2025-01-24T11:40:49","guid":{"rendered":"https:\/\/retirednurseblog.com\/index.php\/2025\/01\/24\/fda-approves-standalone-use-of-jjs-ketamine-derived-depression-treatment-2\/"},"modified":"2025-01-24T11:40:49","modified_gmt":"2025-01-24T11:40:49","slug":"fda-approves-standalone-use-of-jjs-ketamine-derived-depression-treatment-2","status":"publish","type":"post","link":"https:\/\/retirednurseblog.com\/index.php\/2025\/01\/24\/fda-approves-standalone-use-of-jjs-ketamine-derived-depression-treatment-2\/","title":{"rendered":"FDA approves standalone use of J&amp;J\u2019s ketamine-derived depression treatment"},"content":{"rendered":"<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm673y5c700cm2cql5349bu7w@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            The U.S. Food and Drug Administration expanded approval for Johnson &amp; Johnson\u2019s nasal spray, Spravato, to allow it to be used as a standalone treatment for patients with severe depression, the company said on Tuesday.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f00083b6m5z79pdfs@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            The ketamine-derived drug was first approved in 2019 to be used in combination with antidepressants, and later for patients experiencing suicidal thoughts or actions.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f00093b6msonx84ni@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            \u201cNow that it is also available as a monotherapy, healthcare providers have the freedom to further personalize treatment plans based on individual needs,\u201d Gregory Mattingly, founding partner of St. Charles Psychiatric Associates, said in a statement.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f000a3b6m6a1fctrg@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            Spravato bought in sales of $780 million for the first nine months of 2024.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f000b3b6mk8ld6qgv@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            MDD is one of the most common mental health disorders in the U.S., according to the National Institutes of Health. About 21 million U.S. adults in 2021 experienced at least one depressive episodes, latest government data shows.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f000c3b6m87d99imb@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            J&amp;J said that about a third of adults will not respond to oral antidepressants alone.    <\/p>\n<div data-uri=\"cms.cnn.com\/_components\/factbox\/instances\/cm6745ysy000o3b6mp15srw7z@published\" data-component-name=\"factbox\" data-article-gutter=\"true\" class=\"factbox_inline-small factbox_inline-small__\">\n<ul data-editable=\"items\" class=\"factbox_inline-small__items factbox_inline-small__items--ul\">\n<li data-editable=\"items.0.text\" class=\"factbox_inline-small__item inline-placeholder\">Sign up here to get <strong>The Results Are In with Dr. Sanjay Gupta<\/strong> every Friday from the CNN Health team.<\/li>\n<ul><\/ul>\n<\/ul>\n<\/div>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f000d3b6ms0wibc18@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            Spravato\u2019s approval for standalone use is based on a study in which patients treated with the therapy showed a rapid and superior improvement in severity of depressive episodes, compared to placebo.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f000e3b6murraot0s@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            More than a fifth of patients taking Spravato went into remission, the company said.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f000f3b6mitrrfm20@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            The drug works by targeting a neurotransmitter glutamate, which plays a key role in functions. Esketamine, the chemical name for Spravato, is a chemical mirror image of anesthetic ketamine, which is also abused as a recreational party drug and goes by the street nickname \u201cSpecial K\u201d.    <\/p>\n<p class=\"paragraph inline-placeholder vossi-paragraph\" data-uri=\"cms.cnn.com\/_components\/paragraph\/instances\/cm674078f000g3b6mk5f6xh0g@published\" data-editable=\"text\" data-component-name=\"paragraph\" data-article-gutter=\"true\">            J&amp;J said that the mechanism by which esketamine exerts its antidepressant effect is unknown. Due to the potential risk of misuse, Spravato is only available through a restricted program.    <\/p>\n<\/p>\n<div>This post appeared first on cnn.com<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>The U.S. Food and Drug Administration expanded approval for Johnson &amp; Johnson\u2019s nasal spray, Spravato, to allow it to be used as a standalone treatment for patients with severe depression, the company said on Tuesday. The ketamine-derived drug was first approved in 2019 to be used in combination with antidepressants, and later for patients experiencing &#8230;<\/p>\n","protected":false},"author":1,"featured_media":1955,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"loftocean_post_primary_category":0,"loftocean_post_format_gallery":"","loftocean_post_format_gallery_ids":"","loftocean_post_format_gallery_urls":"","loftocean_post_format_video_id":0,"loftocean_post_format_video_url":"","loftocean_post_format_video_type":"","loftocean_post_format_video":"","loftocean_post_format_audio_type":"","loftocean_post_format_audio_url":"","loftocean_post_format_audio_id":0,"loftocean_post_format_audio":"","loftocean-featured-post":"","loftocean-like-count":0,"loftocean-view-count":418,"tinysalt_single_post_intro_label":"","tinysalt_single_post_intro_description":"","tinysalt_hide_post_featured_image":"","tinysalt_post_featured_media_position":"","tinysalt_single_site_header_source":"","tinysalt_single_custom_site_header":"0","tinysalt_single_custom_sticky_site_header":"0","tinysalt_single_custom_sticky_site_header_style":"sticky-scroll-up","tinysalt_single_site_footer_source":"","tinysalt_single_custom_site_footer":"0","footnotes":""},"categories":[35],"tags":[],"class_list":["post-1954","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-news"],"_links":{"self":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/posts\/1954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/comments?post=1954"}],"version-history":[{"count":0,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/posts\/1954\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/media\/1955"}],"wp:attachment":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/media?parent=1954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/categories?post=1954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/tags?post=1954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}