Over the past year, the question has been coming in from everywhere \u2013 from my patients and family members, from colleagues and passengers I chatted with on airplanes: Is Ozempic right for me? Or any of the blockbuster weight loss and diabetes drugs that recently caught the world\u2019s attention? While filming my new documentary about the drugs, it became clear that many people have at least considered taking GLP-1 medications, drawn to the possibility of steadier blood sugar, better heart health and especially weight loss. <\/p>\n
Even though obesity is now one of the most widespread diseases in the developed world, there is still much debate about how it is diagnosed and what exactly causes it. Some experts question whether it is even a disease at all. <\/p>\n
All these topics became the focus of an intense discussion I had in Copenhagen this spring with Dr. Jens Juul Holst, a Danish scientist who helped discover the molecules that are now completely upending the diabetes and weight loss field. By now, you have surely heard of Wegovy, Mounjaro, Zepbound and Ozempic. Some say Holst is a future Nobel Prize winner for this work, while others say he helped further fuel a wildly expensive industry to treat something better addressed with diet and exercise. <\/p>\n
Holst is a delightful, energetic, trim and healthy 79-year-old who still rides his bike to work every day. He explained that the original goal of an international team of researchers was to find a molecule that could possibly treat peptic ulcer disease, not diabetes or obesity. Although it wasn\u2019t ultimately beneficial for ulcers, he told me, it was through a series of serendipitous discoveries that they learned that targeting GLP-1 could instead dramatically lower blood sugar and body weight. And importantly for many who had struggled with obesity, these molecules seemed to work when nothing else had. He knew he had helped discover something potentially transformative. <\/p>\n
When the first versions of these medications were approved 20 years ago, you might be surprised to learn, there was little fanfare. Hardly anyone heard about them during those early days. Part of the reason was the internal handwringing among pharmaceutical executives not at all confident people would inject themselves to lose weight \u2014 and, yes, among scientists like Holst, unclear on what exactly they were treating. <\/p>\n
For starters, there is no question that obesity is linked to all sorts of other diseases, such as type 2 diabetes, cancer, heart disease and stroke, to name a few. However, that doesn\u2019t mean the link always exists for everyone or that obesity was by itself the culprit. After all, there are plenty of people who have obesity but don\u2019t have any evidence of heart disease or diabetes. Their blood pressure is normal, and they take no medications. There are no abnormalities in their blood work or impairments in their normal physical function. Their only disease is an elevated BMI \u2014 too much weight for their height. <\/p>\n
When I asked Karin Conde-Knape, the head of drug development at Novo Nordisk, the maker of Ozempic and Wegovy, about this, she smiled and said, \u201cyes, we call them the \u2018happy obese.\u2019\u201d The concern, she added, is that \u201cthese patients are on a trajectory toward developing these other diseases.\u201d <\/p>\n
Conde-Knape was suggesting that obesity should still be classified as a disease because it will inevitably lead to problems \u2014 even if it doesn\u2019t right now. As things stand now, many major medical organizations, including the American Medical Association and the World Health Organization, would agree with her, but it is still a wildly polarizing topic that has become more urgent than ever with the introduction of these drugs. <\/p>\n
A study published in the Lancet this week projects that in 2050, 43.1 million children and adolescents in the United States and 213 million adults will be overweight or obese. And yet, at a time when we can measure particle size of small lipid molecules and genotype tumors, it is remarkable that we still rely on a primitive method known as BMI to diagnose obesity. <\/p>\n
BMI, or body mass index, is measured with a formula first used nearly 200 years ago, when mathematicians \u2013 not physicians \u2013 were trying to determine the ideal weight for humans; more specifically, \u201cthe quantifiable characteristics of the normal man.\u201d <\/p>\n
Only European men were included in the original measurements \u2013 no women, no children. And it wasn\u2019t until more than a hundred years later, in the 1950s, that insurance companies realized more of their claims were coming from people who were obese. Before that, however, there was no recognized correlation between BMI and overall health. BMI doesn\u2019t even distinguish between muscle mass and fat mass. That\u2019s why the fittest, most chiseled and health-conscious person you know might still be considered obese. <\/p>\n
Holst, along with others, said a better measure of obesity might be the simple use of a tape measure to check your waist-to-hip ratio, which can assess visceral fat, in addition to body mass index. <\/p>\n
The debate about whether obesity should be considered a disease, especially as measured by BMI, will probably continue. But there is an area of agreement I found with nearly everyone I spoke to about the topic: Much like depression and addiction are now described as diseases of the brain, scientists are increasingly saying the same about obesity \u2013 that, for many people, being obese is not a choice or reflective of a lack of willpower. And, interestingly enough, it may be this new class of medications that really reinforced this point. <\/p>\n
Here\u2019s why. <\/p>\n
The GLP-1 molecules are described as post-nutrient hormones, meaning substances the human body releases after consuming food. Collectively, they stimulate your pancreas to make more insulin, slow down how quickly food moves into your intestines and activate areas in the brain that make you feel full or satiated. <\/p>\n
As a neuroscientist, I found this last point particularly fascinating. It turns out that some people never really feel full, no matter how many calories they have consumed. Instead, they have a constant, maddening food chatter in their brains. Even as they\u2019re eating one meal, they are already thinking about the next one, instead of ever feeling truly satiated. It\u2019s part of the reason they continue to eat far more calories than they require. For them, GLP-1 medications can quite literally quiet those voices in their head. <\/p>\n
Holst is also very focused on this particular mechanism of the GLP-1 drugs but worries that it can go too far. <\/p>\n
Over a meal of coffee and tasty pastries, he told me that these drugs seem to take away the joy of food for some people. It is perhaps his biggest concern. People stop socializing as much, he told me, knowing they won\u2019t be hungry for dinner. They may also become too skinny too fast and have the associated sagging skin and fatigue. For others, it is the loss of lean muscle mass that accompanies their weight loss and puts them at greater risk for falls. Because the medications work by slowing digestion, terrible constipation becomes a side effect that is too much for some to bear. <\/p>\n
Consider this: More than half the people who start these medications end up stopping them within just 12 weeks. For some, the medications are too expensive and can eventually become out of reach financially. Others develop a tolerance to the drugs, and over time, they may stop working as well. But for a lot of people, it is these side effects \u2013 including the loss of joy \u2013 that drives their dissatisfaction with the meds. <\/p>\n
And again, it was that loss of joy that was particularly concerning to Holst. \u201cIt is a heavy price to pay,\u201d he told me. <\/p>\n
For now, the question keeps coming: Who should consider taking these drugs? Should I<\/em> try these drugs? <\/p>\n There is little doubt that for most people, regular exercise and eating right is still the best strategy for weight loss and overall health. High-fiber diets, for example tend to release more natural GLP-1. Among people who took GLP-1 medications and stopped, those most likely to keep the weight off had incorporated lifestyle changes in a meaningful way. <\/p>\n Most people do regain weight after stopping the medications, but importantly, not all people and not all the weight. For those able to keep weight off, these medications weren\u2019t a lifelong solution, but rather a burst of motivation to help reverse their obesity trajectory. <\/p>\n Yes, we have a lot of work to do in better defining and assessing obesity. That\u2019s what Holst really wanted me to know after his decades of work on the topic. In the meantime, however, these medications might finally provide a lifeline for those who have truly struggled for too long. <\/p>\n<\/p>\n Over the past year, the question has been coming in from everywhere \u2013 from my patients and family members, from colleagues and passengers I chatted with on airplanes: Is Ozempic right for me? Or any of the blockbuster weight loss and diabetes drugs that recently caught the world\u2019s attention? While filming my new documentary about …<\/p>\n","protected":false},"author":1,"featured_media":1649,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"loftocean_post_primary_category":0,"loftocean_post_format_gallery":"","loftocean_post_format_gallery_ids":"","loftocean_post_format_gallery_urls":"","loftocean_post_format_video_id":0,"loftocean_post_format_video_url":"","loftocean_post_format_video_type":"","loftocean_post_format_video":"","loftocean_post_format_audio_type":"","loftocean_post_format_audio_url":"","loftocean_post_format_audio_id":0,"loftocean_post_format_audio":"","loftocean-featured-post":"","loftocean-like-count":0,"loftocean-view-count":465,"tinysalt_single_post_intro_label":"","tinysalt_single_post_intro_description":"","tinysalt_hide_post_featured_image":"","tinysalt_post_featured_media_position":"","tinysalt_single_site_header_source":"","tinysalt_single_custom_site_header":"0","tinysalt_single_custom_sticky_site_header":"0","tinysalt_single_custom_sticky_site_header_style":"sticky-scroll-up","tinysalt_single_site_footer_source":"","tinysalt_single_custom_site_footer":"0","footnotes":""},"categories":[35],"tags":[],"class_list":["post-1648","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-news"],"_links":{"self":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/posts\/1648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/comments?post=1648"}],"version-history":[{"count":0,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/posts\/1648\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/media\/1649"}],"wp:attachment":[{"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/media?parent=1648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/categories?post=1648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/retirednurseblog.com\/index.php\/wp-json\/wp\/v2\/tags?post=1648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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