When computer scientist Geoffrey Hinton won the Nobel Prize in physics on Tuesday for his work on machine learning, he immediately issued a warning about the power of the technology that his research helped propel: artificial intelligence. <\/p>\n
\u201cIt will be comparable with the Industrial Revolution,\u201d he said just after the announcement. \u201cBut instead of exceeding people in physical strength, it\u2019s going to exceed people in intellectual ability. We have no experience of what it\u2019s like to have things smarter than us.\u201d <\/p>\n
Hinton, who famously quit Google to warn about the potential dangers of AI, has been called the godfather of the technology. Now affiliated with the University of Toronto, he shared the prize with Princeton University professor John Hopfield \u201cfor foundational discoveries and inventions that enable machine learning with artificial neural networks.\u201d <\/p>\n
And while Hinton acknowledges that AI could transform parts of society for the better \u2013 leading to a \u201chuge improvement in productivity\u201d in areas like health care, for example \u2013 he also emphasized the potential for \u201ca number of possible bad consequences, particularly the threat of these things getting out of control.\u201d <\/p>\n
\u201cI am worried that the overall consequence of this might be systems more intelligent than us that eventually take control,\u201d he said. <\/p>\n
Hinton isn\u2019t the first Nobel laureate to warn about the risks of the technology that he helped pioneer. Here\u2019s a look at others who issued similar cautions about their own work. <\/p>\n
The 1935 Nobel Prize for chemistry was shared by a husband-and-wife team, Frederic Joliot and Irene Joliot-Curie (daughter of laureates Marie and Pierre Curie), for discovering the first artificially created radioactive atoms. It was work that would contribute to important advancements in medicine, including cancer treatment, but also to the creation of the atomic bomb. <\/p>\n
In his Nobel lecture that year, Joliot concluded with a warning that future scientists would \u201cbe able to bring about transmutations of an explosive type, true chemical chain reactions.\u201d <\/p>\n
\u201cIf such transmutations do succeed in spreading in matter, the enormous liberation of usable energy can be imagined,\u201d he said. \u201cBut, unfortunately, if the contagion spread to all the elements of our planet, the consequences of unloosing such a cataclysm can only be viewed with apprehension.\u201d <\/p>\n
Nonetheless, Joliot predicted, it would be \u201ca process that [future] investigators will no doubt attempt to realize while taking, we hope, the necessary precautions.\u201d <\/p>\n
Sir Alexander Fleming shared the 1945 Nobel Prize in medicine with Ernst Chain and Sir Edward Florey for the discovery of penicillin and its application in curing bacterial infections. <\/p>\n
Fleming made the initial discovery in 1928, and by the time he gave his Nobel lecture in 1945, already he had an important warning for the world: \u201cIt is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them, and the same thing has occasionally happened in the body,\u201d he said. <\/p>\n
\u201cThe time may come when penicillin can be bought by anyone in the shops,\u201d he went on. \u201cThen there is the danger that the ignorant man may easily underdose himself and, by exposing his microbes to non-lethal quantities of the drug, make them resistant.\u201d <\/p>\n
It was \u201csuch an important and prescient thought so many years ago,\u201d said Dr. Jeffrey Gerber, an infectious diseases physician at Children\u2019s Hospital of Philadelphia and medical director of the Antimicrobial Stewardship Program. <\/p>\n
Nearly a century after Fleming\u2019s initial discovery, antimicrobial resistance \u2013 the resistance of pathogens like bacteria to drugs meant to treat them \u2013 is considered one of the biggest threats to global public health, according to the World Health Organization, responsible for 1.27 million deaths in 2019 alone. <\/p>\n
The key part of Fleming\u2019s warning may have been antibiotics\u2019 excessively wide use rather than the idea of low dosing. <\/p>\n
Paul Berg, who won the 1980 Nobel Prize in chemistry for development of recombinant DNA, a technology that helped jump-start the biotechnology industry, didn\u2019t issue as stark a warning as some of his fellow laureates about the potential risks of his research. <\/p>\n
But he did acknowledge fears around what genetic engineering could lead to, including biological warfare, genetically modified foods and gene therapy, a form of medicine that involves replacing a defective gene that causes disease with a normally functioning one. <\/p>\n
In his 1980 Nobel lecture, Berg focused specifically on gene therapy, saying the approach \u201chas many pitfalls and unknowns, amongst which are questions concerning the feasibility and desirability for any particular genetic disease, to say nothing about the risks.\u201d <\/p>\n
\u201cIt seems to me,\u201d he continued, \u201cthat if we are ever to proceed along these lines, we shall need a more detailed knowledge of how human genes are organized and how they function and are regulated.\u201d <\/p>\n
In an interview decades later, Berg noted that he and other scientists in the field had already come together publicly to acknowledge the potential dangers of the technology and work on guardrails, in a conference known as Asilomar, in 1975. <\/p>\n
\u201cThe concerns about the recombinant DNA or genetic engineering came from the scientists, so that was a very crucial fact,\u201d he told science writer Joanna Rose in 2001, according to a transcript on the Nobel website. <\/p>\n
Through publicly acknowledging the risks and the need to examine them, Berg said, \u201cwe gained an enormous amount of public admiration, if you will, and tolerance, and so we were allowed to actually begin to deal with the question of how can we prevent any dangerous things coming out of our work?\u201d <\/p>\n
By 2001, he said, \u201cthe experience and experiments that have been done have shown that the original concerns which we really believed were possible, in fact, didn\u2019t exist.\u201d <\/p>\n
Now, gene therapy is a growing area of medicine, with treatments approved for sickle cell disease, muscular dystrophy and some inherited forms of blindness, although it\u2019s not widely used because it\u2019s still complicated to administer and very expensive. In its earlier days, the technology led to the death in 1999 of a 17-year-old participant in a clinical trial, Jesse Gelsinger, raising ethical questions about how the research was done and slowing work in the area. <\/p>\n
And though Berg raised concerns himself, he concluded his Nobel lecture in 1980 with a call for optimism and the \u201cneed to proceed.\u201d <\/p>\n
\u201cThe recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries,\u201d he said. \u201cI, for one, would not shrink from that challenge.\u201d <\/p>\n